Overview

Karylief combines nutrients and botanical antioxidants frequently investigated for roles in auditory function, tinnitus perception, mitochondrial/oxidative stress, and microcirculation. The list below compila peer-reviewed studies on individual ingredients commonly associated with these mechanisms (e.g., Magnesium, Alpha-lipoic acid, Coenzyme Q10, Curcumin, and L-Carnitine). These references do not evaluate Karylief as a finished product and are provided strictly for educational purposes.

References

  1. Cevette MJ, et al. Phase II Study Examining Magnesium-Dependent Tinnitus. Otolaryngology (study summary); 2011. doi / PubMed: 22249877.
  2. ClinicalTrials.gov. A Trial of Magnesium-Dependent Tinnitus (NCT01273883).
  3. Quaranta N, et al. The effect of alpha-lipoic acid on temporary threshold shift after noise exposure. Auris Nasus Larynx. 2012.
  4. Sacchetto L, et al. The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Tinnitus: A Systematic Review. Life (Basel). 2023.
  5. Han JS, et al. Safety and Efficacy of Intratympanic Alpha-Lipoic Acid after Acoustic Trauma. Antioxidants. 2022.
  6. Ahn JH, et al. Coenzyme Q10 combined with steroid therapy in sudden sensorineural hearing loss. Clin Otolaryngol. 2010.
  7. Sugahara K, et al. Coenzyme Q10 protects sensory hair cells against aminoglycoside-induced death. PLoS ONE. 2014.
  8. Guastini L, et al. Water-soluble CoQ10 (Q-TER) in chronic sensorineural hearing loss. Otolaryngology–Head and Neck Surg. 2011 (abstract).
  9. Yamaguchi T, et al. Preventive effect of curcumin (including highly bioavailable forms) on noise-induced hearing loss. Hear Res. 2017.
  10. Haryuna TSH, et al. Curcumin reduces cochlear fibroblast damage after noise exposure. 2016.
  11. ClinicalTrials.gov. Effect of Highly Bioavailable Curcumin on Subjective Tinnitus (NCT04800107).
  12. Coleman JKM, et al. Pharmacological rescue of noise-induced hearing loss with N-acetylcysteine and acetyl-L-carnitine. Hear Res. 2007.
  13. Altun Z, et al. Protective effect of acetyl-L-carnitine against cisplatin ototoxicity in auditory cells. Int J Pediatr Otorhinolaryngol. 2013.
  14. Altas E, et al. L-Carnitine reduces radiation-induced cochlear damage (guinea pigs). Ann Clin Lab Sci. 2006.
  15. Portmann D, et al. Randomized double-blind trial: multi-ingredient day/night formula (with magnesium & phytochemicals) alleviates tinnitus-related disability. 2024.
  16. Fujimoto C, et al. Mitochondria-targeted antioxidants for age-related hearing loss: comparative effects of ALCAR, ALA, CoQ10, etc. Antioxidants. 2019.
  17. Swain SK, et al. Tinnitus and its current treatment — overview; notes on vitamins/minerals including magnesium. J Formos Med Assoc. 2016.

Disclaimer

These references are provided for informational and educational purposes only. Karylief is a dietary supplement, not a drug. The studies cited relate to individual ingredients and not to Karylief as a finished product. Results may vary. Always consult a qualified healthcare professional regarding tinnitus or hearing concerns.